Advances and prospects in metabolic engineering of Zymomonas mobilis

Biorefinery of biomass-based biofuels and biochemicals by microorganisms is a competitive alternative of traditional petroleum refineries. Zymomonas mobilis is a natural ethanologen with many desirable characteristics, which makes it an ideal industrial microbial biocatalyst for commercial production of desirable bioproducts through metabolic engineering.

Progress and perspective on lignocellulosic hydrolysate inhibitor tolerance improvement in Zymomonas mobilis

Pretreatment is the key step to overcome the recalcitrance of lignocellulosic biomass making sugars available for subsequent enzymatic hydrolysis and microbial fermentation. During the process of pretreatment and enzymatic hydrolysis as well as fermentation, various toxic compounds may be generated with strong inhibition on cell growth and the metabolic capacity of fermenting strains.

The Laboratory of Professor Shihui YANG

Prof. YANG is "Chutian Scholars" distinguished professor and recipient of Hubei Province "Hundred Talent Program".He received Ph.D. degree in microbiology from University of California at Riverside in 2005. He joined Bioenergy Science Center at Oak Ridge National Laboratory as a Research Associate in 2007, and then National Bioenergy Center at National Renewable Energy Laboratory as a staff Scientist in 2011. He joined Hubei University as a professor of Microbiology since 2016, and his research interest focuses on metabolic engineering, synthetic biology, and renewable bioproducts. He has published 48 papers in prestigious journals including Nature Biotechnology and PNAS with a citation more than 1680 and H-index of 22.


杨世辉,博士,湖北大学生命科学学院教授,博士生导师,湖北省“楚天学者”特聘教授及湖北省“百人计划”专家。湖北大学生物学学士(1993年),武汉大学微生物学硕士(2000年),美国加州大学河滨分校微生物学博士(2005年)。曾先后任职美国能源部橡树岭国家实验室副研究员(Research Associate,2007-2011)及美国国家可再生能源实验室研究员(Staff Scientist,2011-2016)。主要从事微生物代谢工程、合成生物学、系统生物学以及生物能源及重大平台化合物的绿色生物制造等方面的研究,先后在Nature Biotechnology, Science Advances及PNAS等期刊发表论文 48篇,引用1700多次,H-index 23。担任国际学术期刊PLoS ONE 学术编辑,Energies 编辑,Frontiers in Microbiology 主题编辑,Frontiers in Energy Research及Frontiers in Bioengineering and Biotechnology副编辑;Science, PNAS, PLoS Genetics等学术杂志审稿人;多次应邀在国际学术会议上做大会报告并作为会议主持人。

Prof. YANG is "Chutian Scholars" distinguished professor and recipient of Hubei Province "Hundred Talent Program". He received Ph.D. degree in microbiology from University of California at Riverside in 2005. He joined Bioenergy Science Center at Oak Ridge National Laboratory as a Research Associate in 2007, and then National Bioenergy Center at National Renewable Energy Laboratory as a staff Scientist in 2011. He joined Hubei University as a professor of Microbiology since 2016, and his research interest focuses on metabolic engineering, synthetic biology, and renewable bioproducts. He has published 48 papers in prestigious journals including Nature Biotechnology and PNAS with a citation more than 1700 and H-index of 23. He also serves the scientific community as an editor of international journals such as PLoS ONE, Energies, Frontiers in Microbiology, Frontiers in Bioengineering and Biotechnology, and Frontiers in Energy Research; and a reviewer for journals like Science, PNAS, PLoS Genetics, and Biotechnology for Biofuels.

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研究领域

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微生物细胞工厂的理性设计

纤维素资源的高效生物转化

研究成果及论文

Research Achievements

Advances and prospects in metabolic engineering of Zymomonas mobilis

Biorefinery of biomass-based biofuels and biochemicals by microorganisms is a competitive alternative of traditional petroleum refineries. Zymomonas mobilis is a natural ethanologen with many desirable characteristics, which makes it an ideal industrial microbial biocatalyst for commercial production of desirable bioproducts through metabolic engineering.

Complete genome sequence and the expression pattern of plasmids of the model ethanologen...

In this study, we determined the complete chromosome and plasmid sequences of ZM4 and its engineered xylose-utilizing derivatives 2032 and 8b. Compared to previously published and revised ZM4 chromosome sequences, the ZM4 chromosome sequence reported here contains 65 nucleotide sequence variations as well as a 2400-bp insertion.

Progress and perspective on lignocellulosic hydrolysate inhibitor tolerance improvement in Zymomonas mobilis

Pretreatment is the key step to overcome the recalcitrance of lignocellulosic biomass making sugars available for subsequent enzymatic hydrolysis and microbial fermentation. During the process of pretreatment and enzymatic hydrolysis as well as fermentation, various toxic compounds may be generated with strong inhibition on cell growth and the metabolic capacity of fermenting strains.

Identification of inhibitors in lignocellulosic slurries and determination of their effect on hydrocarbon-producing microorganisms

The aim of this work was to identify inhibitors in pretreated lignocellulosic slurries, evaluate high-throughput screening strategies, and investigate the impact of inhibitors on potential hydrocarbon-producing microorganisms. Compounds present in slurries that could inhibit microbial growth were identified through a detailed analysis of saccharified slurries by applying a combination of approaches of high-performance liquid chromatography, GC-MS, LC-DAD-MS, and ICP-MS.



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Events

报告人:戴俊彪

基因组的设计、合成与应用

报告人:Joan W.Bennett

Communication with fungal aroma compounds

报告人:Frank E. Löffler

Nitrogen cycling out of control: the need to renew the nitrogen economy

报告人:Gary Sayler

Volving a systems strategy for biosensing ecological and health risks of PTS in the environment

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